CAHYAWATI, PUTU NITA EFFECT OF SIMVASTATIN ON HISTOPATHOLOGY OF THE HEART AFTER 5/6 SUBTOTAL NEPHRECTOMY. International Journal of Applied Pharmaceutics, 11 (5). p. 2019. ISSN 0975 - 7058
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Internasional2019_EFFECT OF SIMVASTATIN ON HISTOPATHOLOGY OF THE HEART AFTER 56 SUBTOTAL .pdf Download (896kB) | Preview |
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TURNITIN_Effect of simvastatin on histopathology of the heart after 5_6 subtotal nephrectomy,.pdf Download (1MB) | Preview |
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Bukti Korespondensi_IJAP_Effect of simvastatin on histopathology of the heart after 56 subtotal nephrec.pdf Download (125kB) | Preview |
Abstract
Objective: This study aims to assess the condition of cardiac histopathology through hematoxylin-eosin staining in 5/6 subtotal nephrectomy conditions. Methods: Fifteen male Swiss mice aged 3–5 months will be grouped into 3 treatment groups, namely the nephrectomy group (JSN, n=5), sham operation (JSO, n=5), and simvastatin 20 mg/kg body weight (JSIM, n=5). The histopathology of the heart will be assessed blindly. Severity is assessed based on scoring using a scale (−) no damage, (+) mild, (++) medium, and (+++) heavy. Assessment of severity refers to the irregularity of the heart muscle, increased amount of connective tissue, myofibril hypertrophy, myofibril swelling, sarcoplasmic fragmentation, sarcoplasmic vacuolization, bleeding in a myofibril, myofibril degeneration, cardiomyocyte damage, and the presence of acidophilic cytoplasm. Results: The results showed no morphological changes in heart muscle tissue in the JSO group except for fragmentation and vacuolization in minimal amounts of sarcoplasm (+), whereas in the JSN and JSIM groups, there was moderate damage to sarcoplasm (++) and minimal changes in myofibrils (hypertrophy and bleeding) (+). The JSN group also found severe damage (+++) to the irregularity of the heart muscle, whereas in JSIM, only moderate damage was found (++) to the irregularity of the heart muscle. Conclusion: Simvastatin seems to be able to correct the irregularity of the heart muscle in the condition of 5/6 subtotal nephrectomy
| Item Type: | Article |
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| Uncontrolled Keywords: | Cardiac histopathology, Subtotal 5/6 nephrectomy, Simvastatin, Myofibrils. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Institution of Research and Community Service (LP2M) > Medical Education |
| Depositing User: | I Putu Astina |
| Date Deposited: | 05 Mar 2024 07:01 |
| Last Modified: | 05 Mar 2024 07:18 |
| URI: | http://repository.warmadewa.ac.id/id/eprint/2461 |
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